Cureus. National Library of Medicine Pityriasis Rosea after COVID-19 Infection - PubMed Please enable it to take advantage of the complete set of features! Disclaimer. and transmitted securely. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Why rashes that follow COVID vaccines could be a 'good thing' Informed consent: Informed consent has been obtained. Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. The site is secure. government site. There is a growing number of published cases that link PR to COVID-19 infection, with PR appearing either in the acute phase of COVID-19 or, as in our patient, in the post COVID-19 period (4-9). MeSH The average age of incidence was calculated to be 44.92 years, and 63 (62.37%) people presented after administration of the first dose. Careers. The site is secure. Manifestation of pityriasis rosea and pityriasis rosealike eruptions Previously, PR has been reported in temporal association with various viral inoculations. In the period May 2021- February 2022 we observed five cases of clinically typical PR that appeared 2 to 3 weeks after anti-SARS-CoV-2 vaccination with BNT162b2 (3 patients) or mRNA- 1273 (2 patients). 2021 Sep;35(9):e546-e548. J Invest Dermatol. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Rashes show as hives, bumps or . FOIA -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. J Am Acad Dermatol. Disclaimer. Published by Elsevier Inc. Pityriasis rosea. Skin Diseases Associated With COVID-19: A Narrative Review doi: 10.1002/jmv.26549, 9. New urticaria in the weeks after COVID-19 vaccination (March 2023) OTHER DERMATOLOGY. It is possible that a relationship anti- Sars-CoV-2 vaccinationPR/PRLE exists; however, it is very rare, in consideration of millions of vaccinated subjects and the low number of reported cases with PR/PRLE. Dermoscopy showed dotted and linear vessels forming a network on a yellowish background, with some whitish peripheral scales (Figure 3A). reactions included pernio/chilblains, cosmetic ller reactions, zoster, herpes simplex ares, and pityriasis rosea-like reactions. The site is secure. Would you like email updates of new search results? Dermatol Reports. J Formos Med Assoc. Conclusions: We report a spectrum of cutaneous reactions after mRNA COVID-19 vaccines. Pityriasis Rosea Treatment, Causes, Stages, Pictures & Herpes - MedicineNet It is also called Christmas tree rash. Please enable it to take advantage of the complete set of features! 2022;S0738-081X(22)00002-5. It is believed to represent a delayed reaction to viral infections and is usually associated with endogenous systemic reactivation of human herpesvirus (HHV) 6 and / or 7 (1). Dermatol Ther. and transmitted securely. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. Experts propose novel classification for COVID-19 vaccination - Healio Pityriasis rosea and pityriasis rosea-like eruption after anti-SARS-CoV-2 vaccination: a report of five cases and review of the literature. HHS Vulnerability Disclosure, Help All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. 2022 by the American Academy of Dermatology, Inc. Would you like email updates of new search results? doi: 10.1002/iid3.804. J Am Acad Dermatol. Would you like email updates of new search results? 2023 The Authors. Epub 2022 Jan 31. Histopathological Spectrum of Cutaneous Reactions following COVID-19 Vaccine - An Observational Study. Coronavirus pandemic (COVID-19), McMahon D.E., Amerson E., Rosenbach M., et al. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. Pityriasis rosea after Moderna mRNA-1273 vaccine: A case series. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. sharing sensitive information, make sure youre on a federal Pityriasis Rosea: Diagnosis and Treatment | AAFP Epub 2021 Apr 26. Six days later, she developed a rash on her. NS, not specified; PR, pityriasis rosea; PRL, pityriasis rosea-like. It then causes many more small patches. Figure 1. doi: 10.1111/dth.15602. The https:// ensures that you are connecting to the HHS Vulnerability Disclosure, Help Please enable it to take advantage of the complete set of features! Pityriasis rosea is a common self-limiting rash that usually starts with a herald patch on the trunk and progresses along the Langer lines to a generalized rash over the trunk and limbs. HHS Vulnerability Disclosure, Help In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. HHS Vulnerability Disclosure, Help They suggested that the short time elapsed between vaccination and PR onset resembled that of delayed localized cutaneous reactions occurring shortly after the second vaccine dose. Optimized Health and Wellness (Hudson) - Book Appointment Online! doi: 10.1016/j.jaad.2021.03.092, 15. Manifestation of pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccine: A systematic review. In addition to reactivation of HHV-6 or HHV-7, PR can be triggered by some drugs (like angiotensin-converting enzyme inhibitors alone or in combination with hydrochlorothiazide, sartans plus hydrochlorothiazide, allopurinol, nimesulide, and acetyl salicylic acid (2) and vaccines (such as smallpox, poliomyelitis, influenza, human papillomavirus, diphtheria, tuberculosis, hepatitis B, pneumococcus, and yellow fever vaccines) (3). Unlike in our patient, oropharyngeal lesions were observed in approximately 16% of patients with typical PR (10). -, Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosealike eruptions: how to distinguish them? PDF Post SARS-CoV-2 vaccination efuvium - Springer Clin Dermatol. Accessibility Covid: Skin rashes are ONLY symptom for 21% patients, says KCL study 8600 Rockville Pike Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. Your Random Rash Could Be Pityriasis Rosea | Allure doi: 10.1111/jdv.17498. (2016) 55:e33843. Disclaimer. Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. Cutis. Pityriasis rosea (PR) is an acute exanthematous disease. Bethesda, MD 20894, Web Policies It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. Keywords: Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature JAAD Int. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Epub 2022 Feb 9. This site needs JavaScript to work properly. -. Received 2022 Mar 26; Accepted 2022 Apr 25. HHS Vulnerability Disclosure, Help Federal government websites often end in .gov or .mil. Here, we describe a case of PR-like eruption following ChAdOx1 nCoV-19 (AZD1222) vaccination in a Thai patient with glioblastoma. As with eczema, the conditions can be differentiated under the microscope by their acanthotic or non-acanthotic appearance. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Human herpesviruses 6 and 7 are common. National Library of Medicine . Numerous scattered erythematous plaques with fine scale oriented along skin cleavage, Herald patch of pityriasis rosea. It is important for physicians to be aware of this self-limited reaction so they can reassure and appropriately counsel patients that it is safe to receive subsequent vaccine doses despite the cutaneous eruption. government site. 2022 Nov-Dec;67(6):802-804. doi: 10.4103/ijd.ijd_562_22. Numerous scattered erythematous, Pityriasis rosea. Since you said you felt ill at the time getting the vaccine you had covid at the time. However, some hypotheses may be advanced: PR/PRLE following anti-Sars-CoV-2 vaccination may be just a coincidence; anti-Sars-CoV-2 vaccines cause a reactivation of HHV-6 and/or HHV-7; vaccines can induce a delayed hypersensitivity response clinically similar to drug-induced PRLE. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. FOIA -, Rasheed R, Rizwan A, Javed H, Sharif F, Zaidi A. Socioeconomic and environmental impacts of COVID19 pandemic in Pakistanan integrated analysis. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. Unauthorized use of these marks is strictly prohibited. But some patients also are developing delayed skin reactions on. Pityriasis rosea following CoronaVac COVID-19 vaccination: a case report. 2021 Sep 7;8:752443. doi: 10.3389/fmed.2021.752443. The site is secure. The vaccination campaign has been the most important strategy to combat the COVID-19 pandemic. Accessibility Curr Dermatol Rep. 2022;11(4):289-312. doi: 10.1007/s13671-022-00370-9. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. Pityriasis Rosea | Johns Hopkins Medicine 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. 2 min read January 12, 2022 - 6:26AM A Sydney-based woman has credited her booster dose of the Covid-19 vaccine with removing two persistent warts she's had for five years. Pityriasis rosea is generally benign and most of the time will not come back after a patient has recovered, but in a small number of cases the condition recurs which may be a sign, there is another underlying condition causing the rash.. See this image and copyright information in PMC. Factors affecting the severity of central centrifugal cicatricial alopecia. Before -. Pityriasis rosea: Who gets and causes - American Academy of Dermatology 2022 Jul 6;15(1):9503. doi: 10.4081/dr.2022.9503. doi: 10.1159/000517971. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. (2017) 5:20311. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine, Cutaneous adverse reactions after m- RNA COVID-19 vaccine: early reports from Northeast Italy. official website and that any information you provide is encrypted doi: 10.1111/dth.13650, 7. Mohta A, Mohta A, Ghiya BC, Mehta RD, Kumar V. Indian J Dermatol. PRISMA flowchart. They are described as small, itchy blisters found on the trunk of the body and filling with blood, present in middle-aged patients. The .gov means its official. PRISMA, preferred reporting. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. However, the etiopathogenetic mechanisms remain largely unknown and further studies are needed in order to clarify the correlation between SARS-CoV-2 and PR. Disclaimer. "Urticarial lesions" were identified in 19 per cent of COVID-19 patients, likened to a nettle rash with pink or white raised areas of the skin. Catal A, Muoz-Santos C, Galvn- Casas C, et al.. Cutaneous reactions after SARS-COV-2 vaccination: a crosssectional Spanish nationwide study of 405 cases, Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Clipboard, Search History, and several other advanced features are temporarily unavailable. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Epub 2022 Jun 13. The pathogenesis of this relationship is unknown. Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations (2021) 35:e4913. Pityriasis rosea developing after COVID19 vaccination. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. J Eur Acad Dermatol Venereol. Epub 2022 Mar 8. and the adverse cutaneous effects of COVID-19 . Changes in color or texture can result from inflammation, infection, or allergic reactions anywhere on the body. Epub 2022 Jul 19. JAAD Case Rep 2018; 4:8001. Only some cases of PR/pityriasis rosealike eruption (PRLE) after anti-SARS-CoV- 2 vaccination have been reported.1-18 In the period May 2021-February 2022 we observed five cases of clinically typical PR that appeared after anti-SARS-CoV-2 vaccination with BNT162b2 (3 patients) or mRNA-1273 (2 patients). 8:752443. doi: 10.3389/fmed.2021.752443. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. 2023 Mar 3;14(2):207-212. doi: 10.4103/idoj.idoj_449_22. N Engl J Med 2020; 383: 2603-2615. Pityriasis rosea: Signs and symptoms - American Academy of Dermatology World J Clin Cases. Careers, Unable to load your collection due to an error. Cazzato G, Ambrogio F, Foti C, Capuzzolo M, Trilli I, Casatta N, Lupo C, Carrieri M, Daini D, Colagrande A, Maiorano E, Ingravallo G. Diagnostics (Basel). (2019) 34:185764. Department of Pathophysiology and Transplantation, Universit degli Studi, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milan, Italy. 15 Pityriasis rosea and COVID19 S. Veraldi, C. Spigariolo Medicine Journal of medical virology 2020 It's easily mistaken for scalp psoriasis and vice versa. See this image and copyright information in PMC. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. doi: 10.1111/ijd.13061. The https:// ensures that you are connecting to the government site. Federal government websites often end in .gov or .mil. They described a patient developing pityriasis rosea (PR) 2 hours after the second dose of Moderna COVID-19 vaccination. (2020) 83:e5760. Pityriasis rosea, pityriasis rosea-like eruptions, and herpes zoster in the setting of COVID-19 and COVID-19 vaccination. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease. Oral baricitinib for moderate to severe alopecia areata in adolescents . Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). PR is a self-limiting exanthematous disease and herpes zoster is a treatable condition; therefore, their occurrence does not require discontinuation of the vaccination schedule. He denied oropharyngeal lesions. Only a few cases of pityriasis rosea (PR)/pityriasis rosea-like eruption (PRLE) after anti-SARS-CoV-2 vaccination have been reported. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Umakanthan S, Sahu P, Ranade AV, et al. Cases of EM was observed after mRNA-based COVID-19 vaccines, and after CoronaVac vaccination wich is is an inactivated SARS-CoV-2 virus [13, 14]. A 3-cm oval plaque with peripheral scale, larger, MeSH Federal government websites often end in .gov or .mil. . Federal government websites often end in .gov or .mil. We observed 2021;28(16):1992619943. Epub 2021 Jul 21. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. Typically preceded by a primary solitary herald patch followed by the onset of smaller scaly papulo-squamous lesions on the skin tension lines within days to weeks.1 Reactivation of herpes virus 6 and 7 has been incriminated as a . Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. 2021;185(2):e34. Unauthorized use of these marks is strictly prohibited. Would you like email updates of new search results? tions reported after vaccination include: injection site reactions, urticarial and morbilliform eruptions, per-nio/chilblains, reactions to cosmetic llers, herpes zoster, herpes simplex ares, and pityriasis rosea-like rashes [1]. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). doi: 10.1111/dth.13878, 10. tivation is associated with pityriasis rosea-like eruption.6 Our cases of herpes simplex and pityriasis rosea-like eruption occurred in male patients following the first dose of BioNTech, whereas one female patient suffered herpes zoster following the third dose of CoronaVac. Epub 2021 Aug 26. Xing K, Tu XY, Liu M, et al. National Library of Medicine Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. 2021 Sep;60(9):1150-1151.doi: 10.1111/ijd.15700. Methods: But there are important differences between these 2 conditions. eCollection 2022. Br J Dermatol. Epub 2022 Jan 5. Accessibility Drago F, Ciccarese G, Rebora A, et al. We present two cases of COVID-19 vaccine-induced pityriasis rosea. Epub 2021 Nov 2. Postgrad Med J. Safety and efficacy of the BNT162b2 mRNA Covid19 vaccine. Thirty-one studies were included for data extraction after screening following the eligibility criteria. Children often get infected when someone sneezes or kisses them. The latter is found in a younger age group. Br J Dermatol. Central dusky-red erythematous on some plaques (A); almost all lesions fading with associated post-inflammatory hyperpigmentation after treatment (B). JAAD Int. (2021) p. e15040. Pityriasis is linked mainly with herpesviruses 6 and 7; only a small number of cases have been reported in association with vaccinations (e.g., yellow fever, influenza, hepatitis B, human. 2021;35(9):e546e548. doi: 10.1111/jdv.17342. Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. The authors declare no conflict of interest. 8600 Rockville Pike What Conditions Can Be Mistaken For Psoriasis? - Verywell Health NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. Table 1. Epub 2021 Apr 7. This site needs JavaScript to work properly. The papulovesicular and pityriasis rosea-like patterns are equally frequent in all vaccines. government site. The patient developed papulovesicular lesions in the crease lines of the trunk and extremities, four days after inoculation with a recombinant coronavirus vaccine (Covishield, India). Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. Sprinkle bath water with an oatmeal-based bath product (Aveeno). Temiz SA, Abdelmaksoud A, Dursun R, et al.. Pityriasis rosea following SARSCoV- 2 vaccination: a case series. She was prescribed outpatient COVID-19 treatment of azithromycin, vitamins D and C, and then quarantined for 2 weeks. While COVID-19 vaccines offer strong and lasting protection against severe . However, in cases of atypical PR, it may present with erythema multiforme-like lesions and purpura (5). Epub 2022 Feb 9. An official website of the United States government. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. Please enable it to take advantage of the complete set of features! The clinics of HHV-6 infection in COVID-19 pandemic: pityriasis rosea and Kawasaki disease. 10.1136/POSTGRADMEDJ-2020-138234 Careers. See All You will learn Airbrushing, Pinstriping, and Woodgrain. Federal government websites often end in .gov or .mil. government site. This is called the herald patch. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). Pityriasis rosea - NHS SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Epub 2022 Oct 17. J Eur Acad Dermatol Venereol. Khan I, Elsanousi AA, Shareef AM, Tebha SS, Arif A, Gul S. Immun Inflamm Dis. Bethesda, MD 20894, Web Policies 8600 Rockville Pike (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. eCollection 2023 Mar 7. The present study investigated a case of pansclerotic morphea that rapidly progressed a few weeks after infection with COVID-19 in a 57-year-old woman with no history of any autoimmune skin or rheumatic diseases. pityriasis rosea and covid vaccine - classic-jaguar.co.uk J Am Acad Dermatol. Accessibility Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). The rash can be itchy. Tommy came by Kindig-it Design while on vacation, and after a great meeting with Dave, he decided to trade the ocean for the mountains. J Eur Acad Dermatol Venereol. Within two weeks of topical betamethasone dipropionate treatment, the lesions disappeared completely. Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). eCollection 2023 Mar 7. sharing sensitive information, make sure youre on a federal Please enable it to take advantage of the complete set of features! The .gov means its official. Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4). doi: 10.1111/dth.15040. 8600 Rockville Pike doi: 10.1111/dth.15040, 3. doi: 10.12998/wjcc.v5.i6.203, 6. An official website of the United States government. Before Epub 2022 Jun 13. eCollection 2023 Mar-Apr. Vaccinations have been identified to rarely cause several cutaneous reactions. Available doctors, insurances and verified patient reviews for Optimized Health and Wellness. Pityriasis Rosea Induced by COVID-19 Vaccination Eur J Case Rep Intern Med. doi: 10.1111/dth.15601. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. The site is secure. It was found popularly in the trunk area, either asymptomatically or with mild symptoms. All authors have made substantial contribution to the work and have approved the final version of this article. Some patients may have a cold before the rash. Careers. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination Br J Dermatol. Future studies should investigate oral lesions in SARS-CoV-2-positive subjects and after COVID-19 vaccination in the pediatric population, taking into account viral variants and newly developed vaccines. The association between pityriasis rosea and pityriasis rosea-like eruptions after Covid-19 vaccines was established, but given the scarcity of studies, there is a need to conduct different clinical trials to confirm this association further and study the etiology and mechanism of the disease. Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. -, Wollina U, Chiriac A, Kocic H, Koch A, Brzezinski P. Cutaneous and hypersensitivity reactions associated with COVID19 vaccinationa narrative review. Conflicts of Interests: The authors declare there are no competing interests. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. doi: 10.1111/jdv.17342. However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). A 52-year-old Thai woman with a one-year history of recurrent glioblastoma was admitted to our hospital for a planned targeted therapy. Pityriasis rosea developing after COVID19 vaccination PMC FOIA 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Keywords: Several vaccines have been created to counteract the morbidity and mortality associated with COVID19 and stop viral transmission, including the Moderna vaccine (Mrna1273).The mRNA1273 vaccine is a lipid nanoparticle-encapsulated mRNAbased vaccine that encodes the prefusion stabilized fulllength spike . and transmitted securely. 2021;185(2):e34. 2021 Sep;34(5):e15040. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Patients characteristics are reported in Table 1. Only a few cases of pityriasis rosea (PR)/pityriasis rosea-like eruption (PRLE) after anti-SARS-CoV-2 vaccination have been reported. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. Although it is known that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be associated with skin manifestations, a limited number of images are available in the literature at this time. 8600 Rockville Pike Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. J Eur Acad Dermatol Venereol 2020; 34: e436-e437. Drago F, Ciccarese G, Parodi A. Pityriasis rosea and pityriasis rosea-like eruptions: How to distinguish them? COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. Dermatol Reports. Suchonwanit P, Hector CE, Bin Saif GA, McMichael AJ. The SARSCoV2 pandemic plagued the world over the course of the year. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. In all patients laboratory examinations were within normal ranges. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. In 3 patients a biopsy for histopathological examinations was carried out. Cutis. A total of 111 people were identified to have developed pityriasis rosea or pityriasis rosea-like eruptions after vaccination, out of which 36 (55.38%) were female. the reactivation of varicella zoster or herpes simplex infections, pityriasis rosea or rosea-like lesions, petechiae, pernicious purpura .